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Enhanced follicular development and normalized estrous cycles have been reported in obese rodent models

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Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen

Mitochondrial protection by low doses of insulin-like growth factor-I in experimental cirrhosis

These molecular and tissue-level biomarkers are particularly valuable in postmortem toxicology, where they can provide objective evidence of toxicity and cellular mechanism of death, even if the parent compound has been metabolized, cleared from standard matrices, or is difficult to quantify due to decomposition or analytical limitations