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Pharmacotherapy options, such as orlistat, phentermine-topiramate, and naltrexone-bupropion, can support weight loss, though they may cause adverse effects and do not work effectively for all patients

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10.1016/j.ejphar.2006.01.037 38 OrganS

Accumulating evidence suggest that, especially in the colon, EC cells express multiple receptors for the microbiome metabolites, representing a new important link bridging the microbiome to the brain (237, 238)