There is no clinical trial data specifically studying this approach, but some prescribers report anecdotally that patients maintain better long-term responses with periodic dose reductions
Both MTX and 7-hydroxy MTX are excreted by the kidneys, and a small part is also excreted in the bile (Reference Saka and Aouacheri2)
Sourjik & Wingreen, 2012
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3.1 Biological Interpretation of GSH and GSSG Concentrations A decrease in GSH can result from reduced synthesis, oxidation, conjugation, protein S-glutathionylation, export, degradation, or loss of cellular integrity
Recommended daily intake for adults in the UK is 1.5 micrograms, easily achieved through a balanced diet including meat, fish, dairy products, and fortified foods