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Lipid hydroperoxides accumulate in the cellular membranes of lung cells, destabilizing the barrier functions of alveolar epithelial and endothelial cells

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Nauck, et al (1986)

Under oxidative stress these three systems work in concert to detoxify ROS and lipid peroxides, maintain protein structure and function via thiol repair, prevent activation of redox-sensitive inflammatory pathways, and preserve mitochondrial membrane integrity and prevent apoptosis