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In the hypoxia state, XBP1u is activated into XBP1 spliced (XBP1s) by IRE1, enabling effective transcription of multiple target genes in the nucleus

Diabetologia 64 , 22042214 (2021)

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Adipogenic differentiation of thyroid cancer cells through the pax8-ppar fusion protein is regulated by thyroid transcription factor 1 (TTF-1)

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A 2018 meta-analysis of 14 studies with over 1,000 participants found that chitosan, when paired with a calorie-restricted diet and exercise, led to a modest weight loss of about 1 kg over several weeks compared to a placebo group, which actually gained 1.5 kg in some cases