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The GLP-1 receptor is a G protein-coupled receptor that sits on the surface of cells throughout your body

NICE guidance supports bariatric surgery for adults with BMI 40 kg/m or 35 kg/m with obesity-related conditions who have not achieved sustained weight loss through non-surgical measures

While GLP-1 agonists improve overall glycemic controlwhich typically protects nervessome patients report neuropathic symptoms emerging during therapy

Youll lose a significant portion of the dose

Phase 2 data does not capture long-term safety

Triple-Hormone-Receptor Agonist Retatrutide for Obesity Weekly retatrutide injections (1 mg12 mg) resulted in weight reductions of 7.217.5% at 24 weeks and 8.724.2% at 48 weeks in subjects with overweight or obesity (without T2DM) in a phase II, double-blind, randomized, placebo-controlled [125]