At day 6, medium was changed into neuronal maintenance medium consisting of: Neurobasal (Gibco TM , Thermo Fisher Scientific, Netherlands #21103049) containing 1:50 B-27 supplement without vitamin A (Gibco TM , Thermo Fisher Scientific, Netherlands #12587010) and 1:100 GlutaMax (Gibco TM , Thermo Fisher Scientific, Netherlands #35050061)
These treatments aim to reduce inflammation and relieve symptoms
83 It also had no long-term follow-up, so we dont know if the relief was lasting or if any delayed issues occurred
However, urine-organic acid analysis showed a high 5-oxoproline level [1,100 (normal range: 010.0)], suggestive of a defect in GSH metabolism
Kadcyla (T-DM1), in contrast, uses a non-cleavable thioether linker (DM1-SMCC) to release the payload DM1 through antibody degradation, effectively reducing off-target toxicity
Ear Infections: Frequent middle ear infections that may lead to hearing loss