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Think of the elements that lead to weight loss as being like four legs of a chair: exercise, diet, an accountability plan, and medicine

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self-administration in monkeys (Bergman et al., 1989) and thus may have reinforcing effects by this route in people

Signals only observed in the setting of short duration of exposure would be highly suggestive of reverse causality

They work in (slightly) different ways Zepbound and Ozempic also have distinct active ingredients that work in slightly different ways Ozempic targets GLP-1 receptors, while Zepbound targets both GLP-1 and GIP receptors

It's tough sometimes, but seeing the positive impact on my health makes it worth every effort