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12.2 Atopic dermatitis To identify the effects of pterostilbene on atopic dermatitis, topical pterostilbene (0.2, 0.6, and 1% w/w) was applied to DNCB sensitized mice [208]

The GSH/GPX4 node is the crucial regulator of ferroptosis The GSH system, as a lipid peroxide scavenger, has attracted much attention as a potential therapeutic target for ferroptosis

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Its pharmaceutical equivalent, Afamelanotide (Scenesse), was developed by Clinuvel Pharmaceuticals and received EMA approval in 2014 and FDA approval in 2019 for erythropoietic protoporphyria making it the only melanocortin peptide with regulatory approval