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Peroxisome proliferator-activated receptor- (PPAR) agonists improve insulin sensitivity in the liver and skeletal muscles, however, they often cause weight gain and edema, and therefore are generally not recommended in patients with CD (135)

The dynamic lifecycle of the corpus luteum integrates angiogenic, steroidogenic, and apoptotic processes that collectively determine its functional fate ( Figure 9 )

For now, it should be considered a research-only compound, not a proven therapy

One-time prescribing has less value when tolerability and refill timing remain unresolved

In addition, the combination of Exos with antioxidants, iron chelators, or other therapeutic agents could boost their efficacy

Pain, fever, bleeding, abscess formation (pus-filled sacs), and other complications can occur