glp 1 and hrt for perimenopause GLP-1 medications can be helpful, but midlife women, hormones matter too. Early data suggests women using hormone therapy with a GLP-1 may see better results, sometimes at lower doses. This is Are you navigating menopause while

Gastroenterology 132:21312157 Doyle ME, Egan JM (2007) Mechanisms of action of glucagon-like peptide 1 in the pancreas

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Gastrointestinal Side Effects The most common adverse events were gastrointestinal in nature, as expected for this drug class: Nausea the most frequently reported GI side effect, typically most pronounced during dose escalation and diminishing over time Diarrhea reported at moderate frequency Constipation less common than nausea but clinically relevant for some participants Vomiting generally mild and often transient These GI effects are mechanistically linked to GLP-1 receptor activation (slowed gastric emptying, central appetite suppression) and are a recognized feature of all GLP-1-based therapies