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The mixed lineage kinase-like domain, identified as a critical mediator in necroptosis, is then activated by RIPK3 [62]

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Selectins, especially P-selectin, mediate the initial rolling interaction of monocytes with the endothelium (32)

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Most patients experience peak symptoms during the first month of therapy, with gradual improvement thereafter

Symptoms may include facial or throat swelling, difficulty breathing or swallowing, itching or rash, fainting or feeling dizzy, or rapid heartbeat