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Identification and combinatorial engineering of indole-3-acetic acid synthetic pathways in paenibacillus polymyxa

It is very likely that indirect mechanisms (e.g., increased serum cytokines and immune cells) are responsible for most of the effects observed in the whole HPT axis

The development of antibodies, against PD-1 or PD-L1 represents one of the greatest advances to date in the treatment of cancer

Protein-bound uremic toxins (IS, pCS, PAGln) accumulate exponentially as eGFR declines below 60 mL/min/1.73 m 2 due to saturable OAT1/3-mediated tubular secretion (113, 167), with patients at eGFR 30 exhibiting 510 higher IS than those at eGFR 90reflecting clearance impairment rather than unique pathogenic mechanisms