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Phosphorylation of eIF2B prevents it from performing its GTPase activating (GAP) function in association with eIF2 (go to the Protein Synthesis (Translation): Processes and Regulation page for more details) and as a consequence results in reduced translational initiation

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Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review

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