1) has led to the development of the glucagon-like peptide-1 (GLP-1) receptor agonists (RA) as safe and effective treatments for T2D and obesity
This dual-action approach helps Tirzepatide achieve even bigger weight loss results in some people compared to Semaglutide
Because tirzepatide slows stomach emptying, some people notice more reflux shortly after starting treatment, and that reflux can interrupt sleep at night
While these effects arise through different mechanisms, their combination may theoretically increase overall gastrointestinal discomfort in some individuals
doi: 10.23937/2378-3656/1410150 Summary Keywords euglycemic diabetic ketoacidosis (euDKA), SGLT-2 inhibitor, GLP-1 receptor agonist, type 2 diabetes mellitus, adverse drug reaction Citation Gandecka-Pempera A, Naskrt D, Adamska A and Zozuliska-Zikiewicz D (2025) Severe euglycemic ketoacidosis following combined therapy with GLP-1 receptor agonist and SGLT-2 inhibitor, refractory to standard treatment: a case report
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