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According to a recent study, ZnO NPs with hydrophoboic coatings had less toxic effects than those with hydrophilic coatings, possibly owing to the fact that hydrophobic surface coating could decrease bioavailability and thus reduce NP toxicity (Shukla et al., 2015

The bottleneck logic is worth restating because it explains when stacking helps at all: adding a second compound only matters if it clears a different rate-limiting step than the ones already covered

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