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doi:10.1016/s0140-6736(21)00213-0 11.Wadden TA, Bailey TS, Billings LK, et al

La planta de la Garcinia Cambogia es ampliamente comercializada debido a la presencia de compuestos bioactivos, en especial del cido hidroxycitrico

The increase in PKA activity also leads to closure of ATP-sensitive potassium channels, which in turn causes depolarisation of the cell membrane and opening of voltage-dependent calcium channels, resulting in uptake of calcium and stimulation of the exocytosis of secretory granules and thus secretion of insulin

Additionally, the study was registered with ClinicalTrials.gov under ID: NCT05792527

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The SURMOUNT-4 trial specifically examined what happens when individuals who achieved significant weight loss on tirzepatide either continued treatment or switched to placebo