77 Compared with GLP-1, the C-terminus of its amino acid sequence contains 9 additional amino acid residues (PSSGAPPPS), which are not easily degraded by peptide chain endonucleases
The weight loss data confirm that continued treatment beyond 48 weeks produces additional weight reduction: The 28.7% at 68 weeks exceeds the 24.2% at 48 weeks from Phase 2, representing approximately 4.5 additional percentage points of weight loss over the additional 20 weeks of treatment
Phase 2 Trials The findings of phase 1 studies supported the continued clinical development of retatrutide as a promising candidate for the treatment of obesity and T2D
*Based on survey results of 1,243 Ro members taking GLP-1 medication for at least 7 weeks, paired with diet and exercise
Muniyappa, who studies endocrine disorders and runs the diabetes services at the National Institute of Diabetes and Digestive and Kidney Diseases, recommended against bariatric surgery because of the patients age and comorbidities
Oral GLP-1 products should be designed for daily use without harsh side effects