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Tirzepatide (Eli Lilly) SURMOUNT-1 was a 72-week-long Phase III, double-blind, randomized control trial, including 2,500 participants with a BMI over 30, or 27 with more than one weight-related comorbidity thats not type 2 diabetes

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When discontinued, its pharmacological effectsincluding appetite suppression, delayed gastric emptying, and enhanced insulin secretionreverse over approximately five weeks as the drug is eliminated from the body