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This immune activation occurs through multiple pathways including modulation of interleukin signaling and regulation of immune cell differentiation

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158,159,160 Recent research shows that hepatocytes release cholesterol and C-X-C motif chemokine ligand 1 (CXCL1), drawing neutrophils from the bone marrow to the injured liver, where they subsequently secrete HGF to enhance hepatocyte proliferation and support liver regeneration