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Zhang H, Tsao R (2016) Dietary polyphenols, oxidative stress and antioxidant and anti-inflammatory effects

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Consequently, the interaction between TBK1 and TRF3 is disrupted, leading to the suppression of IRF3-mediated IFN-I production [222]

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The dual action creates stronger effects on the digestive system, leading to somewhat higher rates of gastrointestinal side effects