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In the intermediate stage, visual abnormalities may begin to appear, with some patients remaining asymptomatic while others show signs of blurry and distorted vision [21, 22]

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Many of these drugs rely on imported APIs or are manufactured overseas, particularly in countries like China, India, Mexico, and Canada

To address this knowledge gap, here we develop a mathematical model that incorporates the most essential molecular elements for NADPH production, ROS generation, GSH synthesis, and detoxification of ROS by GSH in the outer retina, formed by photoreceptors and the RPE (see Fig