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In a human clinical trial, individuals taking ME-3 gained a remarkable 49% increase in the ratio of reduced to oxidized glutathione

Animal studies have not reported major toxicity, but the lack of comprehensive human data means risks are unknown467

This is the theoretical basis for endogenously supplied gamma-glutamylcysteines ability to raise GSH levels, as being the product of the GCL enzyme, it can be taken up by cells intact, where it feeds directly into glutathione synthase to be converted to glutathione, effectively bypassing the dysfunctional GCL

Singh G, Haileselassie Y, Briscoe L, Bai L, Patel A, Sanjines E, et al

Assessed before proceeding

Unlike topical treatments, IV therapy for skin lightening delivers the antioxidant directly into the bloodstream, allowing for better absorption and more effective results