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Prochlorperazine blocks the D2 dopamine receptors in the brain, which are somatodendritic autoreceptors

GIP (Glucose-dependent Insulinotropic Polypeptide): The addition of GIP agonism provides synergistic effects

Identification of phosphorylation sites in AMP-activated protein kinase (AMPK) for upstream AMPK kinases and study of their roles by site-directed mutagenesis

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This causes physical (body) and psychological (brain) dependence an adaptation that makes it difficult to function without opioids

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