does acetaminophen block glutathione Metabolic fate of acetaminophen. The vast majority of Tylenol & Glutathione Depletion: Clinical

B12 deficiency which is more common, particularly in vegans, older adults, people with gastrointestinal disorders and those who have had gastrointestinal surgery, and people with pernicious anemia is associated with decreased glutathione

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Instead, they believed the irritation was more likely from a fat pad, a bursa, or other connective tissue getting compressed under the IT band (ref)

The short answer: it depends but a reasonable expectation is: At 4 weeks : subtle internal changes and gentle lightening At 8 weeks : more visible brightening and evenness At 12 weeks : notable improvements in tone, radiance, and pigmentation Keep in mind that studies show positive changes in glutathione levels and skin brightness over 412 weeks

Amino Acids , 2012, p

Enhances insulin sensitivity and glucose regulation