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The results from a large retrospective cohort study of 81,573 patients with T2D in the United Kingdom between 2004 and 2006, with follow-up until 2011, showed that the median time to intensification with insulin was 7.1, 6.1, and 6.0 years for those taking 1, 2, or 3 oral glucose-lowering agents, and mean glycated hemoglobin (HbA1c) was 8.7, 9.1, and 9.7%, respectively [19]

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