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Therefore, adjusting the cargo of exosomes and/or engineering their spreading pathways could target cancer cells (especially CSCs) or the TME in order to induce ferroptosis, thus achieving a positive therapeutic outcome

10.1073/pnas.0504423102 170 WangJ

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\n\n\n\n The core mechanisms angiogenesis stimulation through VEGF and VEGFR2 upregulation, nitric oxide pathway modulation, growth hormone receptor sensitization, mTOR pathway interaction, and cytokine regulation provide a coherent and plausible biological framework for understanding the diverse effects observed across species and tissue types in animal studies