00:00:49 Narrator Catch new episodes of Clinical Capsules every 2nd and 4th Tuesdaybringing concise, actionable insights from TRC experts straight to your ears
How Tirzepatide Works Tirzepatide is the first medication that targets two hormones instead of one: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)
Compound Receptors Peak trial weight loss Lean mass as share of loss Semaglutide (Ozempic/Wegovy) GLP-1 ~14.9% (STEP-1, 68 wk) ~39% Tirzepatide (Mounjaro/Zepbound) GLP-1 + GIP ~20.9% (SURMOUNT-1, 72 wk) ~25-40% Retatrutide GLP-1 + GIP + GCGR ~24.2% (Phase 2, 48 wk) Comparable class range Best for understanding the takeaway: the percentage of loss that is lean mass is roughly constant across the class
Because of that, stomach-related side effects tend to occur, particularly in the first few weeks
Authorities seized fake drugs, raw materials, and production machinery
Contraindications and precautions Medical contraindications: Personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 contraindicate GLP-1 receptor agonist use
