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Its anabolic and growth-promoting effects are largely indirect, primarily via stimulation of hepatic IGF-1 production, whilst its direct metabolic effects, particularly those related to lipid metabolism and adipose tissue regulation, are believed to be mediated by specific domains within the GH molecule itself
FASEB Journal (2004) 8
Ectopic tissue releases cytokines, drives oxidative stress, and amplifies pelvic immune activation
Busch et al., 2018)
Annu Rev Physiol
The European Union (EU) Joint Programme-Neurodegenerative Disease Research (JPND) states that by the year 2030, a quarter (25%) of the European population will be over age 65, a significant increase over the current 16% [1]
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