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"The HCSC transaction closed later than the company's financial planning assumptions, increasing the first quarter Cigna Healthcare [MLR] as the Medicare businesses operate at a higher [MLR] compared to the rest of the portfolio," the company wrote in its filing

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Most importantly, a noteworthy feature of our model is that we have used primary PSC preparations from several different patients to account for the now well-recognised heterogeneity of PSCs within cancer stroma

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