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Most therapeutic research remains centered around experimental models of disease in rodents with limited work in the larger species, arguably narrowing the utility of these findings in horses on a clinical level
As discussed in the previous section, there are two enzymes of creatine synthesis, glycine amidinotransferase (encoded by the GATM gene ) and guanidinoacetate N -methyltransferase (encoded by the GAMT gene), and one major creatine transporter encoded by the SLC6A8 gene
It is one of the most studied peptides for N-to-B targeting in CNS disorders [90,91,92,93,94]
10.1021/jf980985s 54 WangR.HalimulatiM.HuangX.MaY.LiL.ZhangZ
Access this article Similar content being viewed by others Data Availability All data generated or analysed during this study are included in this published article and its supplementary information files