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This induction is primarily mediated through the activation of the heme-regulated eIF2 kinase (HRI), which leads to increased ATF4 translation and the subsequent activation of genes involved in the stress response, highlighting UTXs role in modulating cellular stress pathways and its potential impact on cancer progression (Kitajima et al., 2021)

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Cindy Wassef, a dermatologist at Premier Health Associates in Randolph, N.J