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doi: 10.3389/fendo.2022.1062790 28 HornsteinMD

doi: 10.2337/diabetes.53.3.654 34 DeaconCFPridalLKlarskovLOlesenMHolstJJ

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[1] This abnormal keratinization and skin cell proliferation combined with down-regulating 5-Reductase (due to insufficient IGF-1) [19] eventually atrophies the sebaceous glands by reducing sebocyte proliferation that would typically be induced by DHT, if not for the loss of 5-Reductase regulation from IGF-1