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Several pathologies are related to lowered mitochondrial Glutathione, including hypoxia (low levels of oxygen in body tissues), aging, liver diseases and neurologic disorders

The other reason is due to decreased uridine diphosphate glucuronosyltransferase activity in liver cells which results in decreased bilirubin conjugation in the liver

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High-performance liquid chromatography (HPLC) and enzyme-linked immunosorbent assay (ELISA) were employed to quantify the levels of these key neurotransmitters and neurotrophic factors

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