retatrutide clinical trials latest How to Get in 2026 Phase III retatrutide study demonstrates

doi: 10.1038/nm919 31 SalcedoITweedieDLiYGreigNH

Glucagon is known to have positive chronotropic and inotropic properties, meaning it can increase both heart rate and the force of cardiac contractions

Semaglutide (Ozempic, Rybelsus) is the most commonly prescribed

Systemic side effects observed in retatrutide trials are broadly consistent with the GLP-1 receptor agonist class and include nausea, vomiting, diarrhoea, constipation, decreased appetite, and fatigue

However, Mounjaro additionally activates GIP (glucose-dependent insulinotropic polypeptide) receptors, which may contribute to the greater average weight loss observed in Mounjaro clinical trials compared with GLP-1-only treatments

In the stomach, it slows emptying, so food leaves more gradually and the post-meal glucose curve flattens