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Furthermore, improved ease of use could lead to better long-term weight management and diabetes control, but this remains a subject of ongoing research

of the 15 medications evaluated, topiramate was the only medication that demonstrated a statistically significant response for weight loss

The problem was the side effects associated, particularly with GLP-1, are what we call peak to trough: so the difference between the highest amount of drug and the lowest and then going back up again to the highest caused by this twice-a-day dosingwhich you can imagine someone bouncing around maybe two to three times, the drug at peak, then trough, causes a lot of GI distress

Dinsen, S., Baslund, B., Klose, M., Rasmussen, A

Br J Cancer 1996