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Synaptic density: Microscopy studies confirm increased dendritic spine density in Dihexa-treated animals, providing structural evidence for the observed cognitive improvements

Low platelet count is often discovered incidentally during routine blood work

Not approved by the Australian Therapeutic Goods Administration (TGA) for therapeutic use

Because autophagy is a protective mechanism involved in the removal of dysfunctional proteins and/or organelles, its inhibition may contribute to the toxicity of Efavirenz and/or the development of neurodegenerative diseases in HIV patients treated with this drug (Bertrand and Toborek 2015)

Generally, canonical Wnt cascades such as Wnt3a can stimulate insulin secretion and enhance the proliferation of cell by activating -catenin/TCF/LEF-mediated Cyclin D1 transcription