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Germ-free mice were obtained from the University of North Carolina Gnotobiotic Facility, which is supported by P30-DK034987-25-28 and P40-RR018603-06-08

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That is why side effects can persist after a dose is skipped or treatment is stopped, and why any change in a regimen takes weeks rather than days to fully express in blood levels

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Taste changes occur in a subset of patients and can appear within 510 days

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