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Patients should inform their physician if they have: Personal history of any cancer, including colorectal cancer or polyps Family history of colorectal cancer, especially in first-degree relatives Inflammatory bowel disease (Crohn's disease or ulcerative colitis) Genetic syndromes associated with increased cancer risk (Lynch syndrome, familial adenomatous polyposis) Previous radiation therapy to the abdomen or pelvis These factors affect baseline colorectal cancer risk independent of medication use

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10.1002/adfm.201902634 30 MauriE.SalvatiA.CataldoA.MozeticP.BasoliF.AbbruzzeseF.et al (2021)

Transcriptional regulators of the enzymes include the peroxisome proliferator-activated receptors (PPARs) and a transcription factor coactivator PGC-1a (and involve the retinoid X receptor), but the details of the process are tissue dependent