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Thus, future studies need to identify the genes responsible for GSH biosynthesis and the cellular mechanisms underlying the regulation of enzymes related to GSH metabolism or degradation

This dysregulated metabolism creates an environment characterized by persistent oxidative stress, chronic inflammation, and altered energy signaling, which collectively drive fibrosis and cellular transformation (Ding et al., 2025

The inhibition of ChoK suppressed the pathogenic behavior of RA-FLS, limiting cell migration and resistance to apoptosis, which may contribute to cartilage destruction in RA

And no, spacing doses apart on a weekly basis does not re-sensitize receptors or prevent this internalization