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Rare diseases (HST) : For populations typically under 3000 patients in England, the HST program allows high thresholds (up to 100k300k/QALY) reflecting societal preference to reward innovation for rare conditions ( [5] )

And metformin, a common medication to treat prediabetes and type 2 diabetes, can also cause diarrhea

Potential mechanisms for glutamate cysteine ligase activation in sepsis involve a decreased ratio of reduced/oxidized glutathione as well as the effects of reactive oxygen species, nitric oxide species, proinflammatory cytokines, heat shock proteins, and physical inactivity

The drugs can slow digestion so much that it puts patients at increased risk for the problem, called pulmonary aspiration, which can cause dangerous lung damage, infections and even death, said Dr

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