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Wang et al., 2014c

These findings indicate that the inflammatory microenvironment not only accelerates ECM degradation but also directly regulates ferroptosis pathways in IDD

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L-carnitine plays an important role in lipid metabolism as it transports long-chain fatty acids to the mitochondria, where they are transformed (beta-oxidized) to generate the energy necessary for cell function

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Concurrently, it interferes with noncanonical pathways, including the Wnt/-catenin and NF-B pathways, thereby maintaining epithelial cell polarity and structural integrity and suppressing EMT and ECM deposition (35)