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Cr, creatinine

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ERK5 is a two-kinase transcription factor, and phosphorylation of ERK5 S496 directly inhibits NRF2 protein activity through SUMOylation modification at site 518, an inhibitory effect that can lead to inflammation and mitochondrial dysfunction in macrophages [133]

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Rather than sedating, it appears to normalize disrupted sleep architecture in animal and small human studies