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The retatrutide + cagrilintide stack is the most aggressive metabolic peptide combination community sources currently describe a triple-agonist GLP-1/GIP/glucagon backbone (retatrutide) layered with a long-acting amylin analog (cagrilintide)

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Thus, a screen for these medications is necessary to determine this as the cause

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Participants receiving the highest dose of retatrutide experienced a mean weight loss of 24.2% of their body weight, equivalent to about 58 pounds [R]