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A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity

We noted that ECLs are constitutively flexible without agonist binding, thereby posing a conformation different from those observed in both active and inactive states

M., Neklason, D

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Back Laughton, NB, Macallum, AB (1 June 1932) 'The Relation of duodenal mucosa to internal secretion of the pancreas', Proceedings of the Royal Society of London

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