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In the HPS2-THRIVE study, also no additional clinical benefit was observed from treatment with prolonged-release niacin and laropiprant (a compound that inhibits prostaglandin D2 synthesis responsible for skin flushing and hot flashes) in combination with a statin [204]

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Integration of gene-based approaches, targeted delivery systems, and biomarker-guided interventions may establish riboflavin as a key component of precision medicine strategies for neurological disorders