They follow a similar titration schedule, but their maximum allowable doses only reach 2.4 mg for Wegovy and 2 mg for Ozempic
Because semaglutide slows gastric emptying and affects appetite, some people feel slightly off when fasting or skipping meals, especially early in treatment
ClinicalTrials.gov registrations: Phase 2 trial NCT04881760
Key Takeaways Administration (in-office injection) is viable in all 50 states under medical board oversight Dispensing (at-home supply) is prohibited or severely restricted in major markets The FDA shortage resolution ended enforcement discretion for compounded GLP-1s State pharmacy dispensing permits are non-negotiable if you dispense medications Mid-level practitioner authority for dispensing varies significantly by state Medical director oversight is the legal foundation for any GLP-1 program 503B office use stock cannot be redistributed for at-home patient use Non-compliance creates practice-ending legal exposure

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[4] As a result, GLP-1 agonists are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or those with multiple endocrine neoplasia syndrome type 2 (MEN 2), a genetic disorder that increases the risk of certain types of tumors