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Assi, R, Benton CB, Al Rawi A, Chamoun K, Wang F, Pierce S, Patel KP, Hamilton BK, DiNardo CD, Garcia-Manero G, Kantarjian HM, Kadia T

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The peptide specifically targets cells that have already undergone senescence, effectively clearing them from tissues without compromising normal cellular function or predisposing tissues to acute damage

For example, El-Lebedy (2019) reported reduced circulating METRNL levels in individuals with type 2 diabetes and obesity compared with controls, whereas Dadmanesh et al

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It is crucial to note that in most CVOTs the primary endpoint was a composite endpoint of major adverse cardiovascular events (MACE), with HF hospitalisation typically a prespecified secondary or exploratory outcome