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We find that our inhibitors are reversible, while known covalent TGR inhibitors 20,45 , including AF, Stattic, and TRi-1, are irreversible (Fig

doi: 10.1016/S0140-6736(18)32261-X 42 GersteinHCColhounHMDagenaisGRDiazRLakshmananMPaisPet al

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A number of mechanisms have been proposed to underlie the proatherogenic properties of sdLDL, including increased susceptibility of oxidation (464) and glycation (465), promoting arterial retention and increased macrophage foam cell formation