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With an active Phase 3 program and FDA Fast Track designation, apitegromab is positioned as the most clinically advanced selective myostatin inhibitor currently in development.

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10.1136/bmjopen-2020-046235 91

Tirzepatide at its MTD showed the greatest effect, with an MD of 20.90% (95% CI: 24.93 to 16.87), followed by tirzepatide 15 mg (MD: 18.08%